Title : Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation.

Pub. Date : 2011 Apr 25

PMID : 21334318






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cafestol-induced apoptosis is associated with the reduction of mitochondrial membrane potential (MMP), activation of caspase 3, cytochrome c release, and down-regulation of anti-apoptotic proteins (Bcl-2, Bcl-xL, Mcl-1 and cFLIP). cafestol BCL2 apoptosis regulator Homo sapiens
2 Ectopic expression of Bcl-2 or Mcl-1 in Caki cells attenuates cafestol-induced apoptosis. cafestol BCL2 apoptosis regulator Homo sapiens