Title : Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition.

Pub. Date : 2011 Apr 25

PMID : 21333771






1 Functional Relationships(s)
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1 In addition, PXR and GR are key regulators of intermediary metabolism (e.g. carbohydrate, lipids or bile acids homeostasis) and many other cellular functions (e.g. immune response), hence, the interactions between azoles and PXR/GR are of broader physiological importance. Bile Acids and Salts nuclear receptor subfamily 1 group I member 2 Homo sapiens