Title : Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-κB signaling pathway.

Pub. Date : 2011 Apr

PMID : 21327328






1 Functional Relationships(s)
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1 Using the p38 inhibitor, SB203580, the ERK1/2 inhibitor PD98059, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate and the NAMPT inhibitor FK866, we demonstrated that the visfatin pro-inflammatory action was through the NAMPT-MAPK (p38, ERK1/2)-NF-kappaB pathway. pyrrolidine dithiocarbamic acid nicotinamide phosphoribosyltransferase Homo sapiens