Pub. Date : 2011
PMID : 21325824
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | The present study aimed at understanding AMPK signals for adenosine-induced HuH-7 cell apoptosis. | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Adenosine activated AMPK, to phosphorylate Bcl-X(L). | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Adenosine or AICAR disrupted mitochondrial membrane potentials, and the effect was inhibited by knocking-down AMPKalpha1 and/or AMPKalpha2, expressing dominant negative mutant AMPKalpha2 or mutant Bcl-X(L) lacking Ser/Thr phosphorylation sites. | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Adenosine or AICAR disrupted mitochondrial membrane potentials, and the effect was inhibited by knocking-down AMPKalpha1 and/or AMPKalpha2, expressing dominant negative mutant AMPKalpha2 or mutant Bcl-X(L) lacking Ser/Thr phosphorylation sites. | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | CONCLUSION: Adenosine activates AMPK, to disrupt mitochondrial membrane potentials through Bcl-X(L) phosphorylation, allowing DIABLO release from the mitochondria, as a factor for caspase-3 activation to induce HuH-7 cell apoptosis. | Adenosine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |