Pub. Date : 2011
PMID : 21325821
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The substances interfere with the activation and nuclear translocation of nuclear factor NFkappaB, by inhibiting NFkappaB directly (parthenolide) or by interfering with the inactivation of the NFkappaB inhibitory protein IkappaB-alpha (Bay 11-7082). | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | The substances interfere with the activation and nuclear translocation of nuclear factor NFkappaB, by inhibiting NFkappaB directly (parthenolide) or by interfering with the inactivation of the NFkappaB inhibitory protein IkappaB-alpha (Bay 11-7082). | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The substances interfere with the activation and nuclear translocation of nuclear factor NFkappaB, by inhibiting NFkappaB directly (parthenolide) or by interfering with the inactivation of the NFkappaB inhibitory protein IkappaB-alpha (Bay 11-7082). | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Targeting the NFkappaB pathway by Bay 11-7082 (IC(50) 10 muM) and parthenolide (IC(50) 30 muM) triggered suicidal erythrocyte death as shown by annexin V binding and decrease of forward scatter. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | In conclusion, the pharmacological inhibitors of NFkappaB, Bay 11-7082 and parthenolide, interfere with the survival of erythrocytes involving mechanisms other than disruption of NFkappaB-dependent gene expression. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |