Title : Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.

Pub. Date : 2011 May

PMID : 21324916






2 Functional Relationships(s)
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1 In 3T3-L1 adipocytes, addition of GW7647, a highly specific PPARalpha agonist, during adipocyte differentiation enhanced glycerol-3-phosphate dehydrogenase activity, insulin-stimulated glucose uptake, and adipogenic gene expression. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 Chromatin immunoprecipitation (ChIP) assay revealed that PPARalpha was recruited to promoter regions of both adipogenic and FA oxidation-related genes in the presence of GW7647 in 3T3-L1 adipocytes. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus