Title : Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms.

Pub. Date : 2011 Jun

PMID : 21320636






2 Functional Relationships(s)
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1 The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human, and genistein administration improved liver function, slowed down NASH progression, decreased the levels of TBARS, TNF-alpha and IL-6 in serum and liver, as well as inhibited IkappaB-alpha phosphorylation, nuclear translocation of NF-kappaB p65 subunit, and activation of c-Jun N-terminal kinase (JNK). Genistein mitogen-activated protein kinase 8 Homo sapiens
2 The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human, and genistein administration improved liver function, slowed down NASH progression, decreased the levels of TBARS, TNF-alpha and IL-6 in serum and liver, as well as inhibited IkappaB-alpha phosphorylation, nuclear translocation of NF-kappaB p65 subunit, and activation of c-Jun N-terminal kinase (JNK). Genistein mitogen-activated protein kinase 8 Homo sapiens