Title : Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

Pub. Date : 2011 Mar 2

PMID : 21317875






1 Functional Relationships(s)
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1 We show that the Xbp1-specific ribonuclease activity depends on autophosphorylation, and that ATP-competitive inhibitors staurosporin and sunitinib, which inhibit autophosphorylation in vitro, also inhibit Xbp1 splicing in vivo. Adenosine Triphosphate X-box binding protein 1 Homo sapiens