Title : Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier.

Pub. Date : 2011 Apr 4

PMID : 21309545






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) combination knockout mice display disproportionately increased brain penetration of shared substrates, including topotecan and several tyrosine kinase inhibitors, compared to mice deficient for only one transporter. Topotecan ATP binding cassette subfamily B member 1 Homo sapiens