Title : Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier.

Pub. Date : 2011 Apr 4

PMID : 21309545






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 For sorafenib transport, ABCG2 was the major determinant at low concentrations. Sorafenib ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus
2 However, saturation of ABCG2-mediated transport occurred at higher sorafenib concentrations, where ABCB1 was still fully active. Sorafenib ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus