Title : Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes.

Pub. Date : 2011 Jul

PMID : 21301813






3 Functional Relationships(s)
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1 RESULTS: Treatment of astrocytes with fluoxetine and paroxetine, another SSRI antidepressant, upregulated brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and VGF mRNA expression. Paroxetine brain derived neurotrophic factor Homo sapiens
2 RESULTS: Treatment of astrocytes with fluoxetine and paroxetine, another SSRI antidepressant, upregulated brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and VGF mRNA expression. Paroxetine brain derived neurotrophic factor Homo sapiens
3 Our results also indicate that the effects of fluoxetine and paroxetine on glucose utilization, lactate release, and expression of BDNF, VEGF, and VGF are not mediated by serotonin-dependent mechanisms. Paroxetine brain derived neurotrophic factor Homo sapiens