Title : Regulation of vascular guanylyl cyclase by endothelial nitric oxide-dependent posttranslational modification.

Pub. Date : 2011 Jun

PMID : 21298436






2 Functional Relationships(s)
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1 When compared with transgene negative controls (eNOS(n)), eNOS(++)-mice showed a 3.3-fold higher endothelial-specific aortic eNOS expression, increased vascular cGMP and VASP phosphorylation, a L-nitroarginine (L-NA)-inhibitable decrease in systolic blood pressure, but normal levels of peroxynitrite and nitrotyrosine formation, endothelium-dependent aortic vasodilation and vasodilation to NO donors. H-Arg(NO2)-OH nitric oxide synthase 3, endothelial cell Mus musculus
2 When compared with transgene negative controls (eNOS(n)), eNOS(++)-mice showed a 3.3-fold higher endothelial-specific aortic eNOS expression, increased vascular cGMP and VASP phosphorylation, a L-nitroarginine (L-NA)-inhibitable decrease in systolic blood pressure, but normal levels of peroxynitrite and nitrotyrosine formation, endothelium-dependent aortic vasodilation and vasodilation to NO donors. H-Arg(NO2)-OH nitric oxide synthase 3, endothelial cell Mus musculus