Title : Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.

Pub. Date : 2011 Jun 1

PMID : 21291942






1 Functional Relationships(s)
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1 MPTP administration significantly impaired mitochondrial complex-I activity and redox activity, upregulated the caspase-3 and NF-kappaB levels as compared to vehicle group. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine caspase 3 Mus musculus