Title : Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.

Pub. Date : 2011 Jun 1

PMID : 21291942






3 Functional Relationships(s)
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1 Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytochrome c oxidase II, mitochondrial Mus musculus
2 The present study was focused on the possible neuroprotective effect of selective cyclooxygenase (COX)-2-inhibitors: valdecoxib and NS-398 in 1-methyl-4-phenyl-1,2,3,6-tertahydropyridine (MPTP)-induced neurotoxicity in mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytochrome c oxidase II, mitochondrial Mus musculus
3 The findings of the present study substantiate the neuroprotective role of selective COX-2 inhibitors in ameliorating MPTP-induced neurodegeneration in mice and suggest the possible therapeutic potential of these drugs in the management of PD. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytochrome c oxidase II, mitochondrial Mus musculus