Title : Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.

Pub. Date : 2011 May

PMID : 21289076






1 Functional Relationships(s)
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1 The CYP2C8 inhibitors gemfibrozil 1-O-beta glucuronide and trimethoprim inhibited the depletion of 0.02 muM montelukast and formation of M6 from 0.05 muM montelukast more potently than did the CYP2C9 inhibitor sulfaphenazole. Trimethoprim cytochrome P450 family 2 subfamily C member 9 Homo sapiens