Title : Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

Pub. Date : 2011 Jul 1

PMID : 21285291






1 Functional Relationships(s)
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1 Activation of Ang II-stimulated signalling pathways in the ACE2-deficient myocardium was associated with increased expression and phosphorylation of p47(phox), NADPH oxidase activity, and superoxide generation, leading to enhanced MMP-mediated degradation of the extracellular matrix. Superoxides angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus