Title : Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Pub. Date : 2011 Jan 28

PMID : 21276940






1 Functional Relationships(s)
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Protein Name
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1 Cocrystal structures of KH-CB19 with CLK1 and CLK3 revealed a non-ATP mimetic binding mode, conformational changes in helix alphaC and the phosphate binding loop and halogen bonding to the kinase hinge region. Phosphates CDC like kinase 1 Homo sapiens