Pub. Date : 2011 Apr 15
PMID : 21270111
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Autophagy was activated in response to fenretinide or bortezomib in B-RAF wild-type cells, shown by increased conversion of LC3 to the autophagic vesicle-associated form (LC3-II) and redistribution to autophagosomes and autolysosomes, increased acidic vesicular organelle formation and autophagic vacuolization. | Fenretinide | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | Knockdown of Beclin-1 or ATG7 sensitized B-RAF wild-type cells to fenretinide- or bortezomib-induced cell death, demonstrating a pro-survival function of autophagy. | Fenretinide | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | In addition, autophagy was partially reactivated in B-RAF-mutated cells treated with the BH3 mimetic ABT737 in combination with fenretinide or bortezomib, suggesting autophagy resistance is partly mediated by abrogated Beclin-1 function. | Fenretinide | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |