Pub. Date : 2011 Sep
PMID : 21268135
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. | methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate | PTTG1 regulator of sister chromatid separation, securin | Homo sapiens |
| 2 | In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. | methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate | PTTG1 regulator of sister chromatid separation, securin | Homo sapiens |
| 3 | In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. | methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate | PTTG1 regulator of sister chromatid separation, securin | Homo sapiens |
| 4 | This study demonstrates for the first time that drugs, such as CDODA-Me and CF(3)DODA-Me, that decrease Sp protein expression also downregulate PTTG-1 in thyroid cancer cells and therefore have potential for clinical treatment of thyroid cancer and other endocrine neoplasias where PTTG-1 is a major pro-oncogenic factor. | methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate | PTTG1 regulator of sister chromatid separation, securin | Homo sapiens |
| 5 | This study demonstrates for the first time that drugs, such as CDODA-Me and CF(3)DODA-Me, that decrease Sp protein expression also downregulate PTTG-1 in thyroid cancer cells and therefore have potential for clinical treatment of thyroid cancer and other endocrine neoplasias where PTTG-1 is a major pro-oncogenic factor. | methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate | PTTG1 regulator of sister chromatid separation, securin | Homo sapiens |