PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21268135-4 2011 In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate 139-147 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 13-48 21268135-4 2011 In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate 139-147 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 50-56 21268135-4 2011 In addition, pituitary tumor-transforming gene-1 (PTTG-1) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF(3)DODA-Me and this was accompanied by decreased expression of PTTG-1-dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate 139-147 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 216-222 21268135-6 2011 This study demonstrates for the first time that drugs, such as CDODA-Me and CF(3)DODA-Me, that decrease Sp protein expression also downregulate PTTG-1 in thyroid cancer cells and therefore have potential for clinical treatment of thyroid cancer and other endocrine neoplasias where PTTG-1 is a major pro-oncogenic factor. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate 63-71 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 144-150 21268135-6 2011 This study demonstrates for the first time that drugs, such as CDODA-Me and CF(3)DODA-Me, that decrease Sp protein expression also downregulate PTTG-1 in thyroid cancer cells and therefore have potential for clinical treatment of thyroid cancer and other endocrine neoplasias where PTTG-1 is a major pro-oncogenic factor. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate 63-71 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 282-288