Pub. Date : 2011 May
PMID : 21266595
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, midazolam 1"-hydroxylation catalyzed by recombinant CYP3A5 was enhanced by the coexistence of sorafenib or sunitinib in a concentration-dependent manner, with saturation occurring at approximately 10 muM. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | Our results thus showed that sorafenib and sunitinib activated midazolam 1"-hydroxylation by CYP3A5 but inhibited that by CYP3A4. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Unexpected drug interactions involving sorafenib and sunitinib might occur via heterotropic cooperativity of CYP3A5. | Sorafenib | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |