Title : Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects.

Pub. Date : 1990 Dec

PMID : 2126612






7 Functional Relationships(s)
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1 We used specific radioimmunoassays to measure TRH-Gly and TRH levels in rat cortex, hypothalamus, medulla, eyes and whole blood as a function of the intracisternal (IC) dose of TRH and TRH-Gly administered 40 min prior to sacrifice. Glycine thyrotropin releasing hormone Rattus norvegicus
2 The relative potency of IC and intracardiac (IK) TRH and TRH-Gly release of rat TSH was compared by radioimmunoassay and further refined using estimates based on in vivo kinetics of TRH-Gly alpha-amidation. Glycine thyrotropin releasing hormone Rattus norvegicus
3 The relative potency of IC and intracardiac (IK) TRH and TRH-Gly release of rat TSH was compared by radioimmunoassay and further refined using estimates based on in vivo kinetics of TRH-Gly alpha-amidation. Glycine thyrotropin releasing hormone Rattus norvegicus
4 IK TRH-Gly had 0.16% of the potency of IK TRH of TSH release and was also consistent with its rate of intravascular conversion to TRH. Glycine thyrotropin releasing hormone Rattus norvegicus
5 IK TRH-Gly had 0.16% of the potency of IK TRH of TSH release and was also consistent with its rate of intravascular conversion to TRH. Glycine thyrotropin releasing hormone Rattus norvegicus
6 IK TRH-Gly had 0.16% of the potency of IK TRH of TSH release and was also consistent with its rate of intravascular conversion to TRH. Glycine thyrotropin releasing hormone Rattus norvegicus
7 The mean peak TSH response occurred at 20 min after IC TRH-Gly or IC TRH injection but the post-peak decline was slower for IC TRH-Gly. Glycine thyrotropin releasing hormone Rattus norvegicus