Title : FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.

Pub. Date : 2011 Mar 24

PMID : 21263155






1 Functional Relationships(s)
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1 In vitro, exogenous FL at concentrations similar to those observed in patients mitigated FLT3 inhibition and cytotoxicity for each of 5 different FLT3 inhibitors (lestaurtinib, midostaurin, sorafenib, KW-2449, and AC220). KW 2449 fms related receptor tyrosine kinase 3 ligand Homo sapiens