Protein Name fms related receptor tyrosine kinase 3 ligand
Organism Homo sapiens
Gene ID 2323
Gene Symbol

FLT3LG

UniProt P49771 (FLT3L_HUMAN), M0QYM9 (M0QYM9_HUMAN), B7ZLY4 (B7ZLY4_HUMAN)
Relationships Total Number of functionally related compound(s) : 122
Total Number of Articles : 92
Description

fms related receptor tyrosine kinase 3 ligand

Gene Summary

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

synonyms
  • fms-related tyrosine kinase 3 ligand
  • flt3 ligand
  • fms related tyrosine kinase 3 ligand
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Properties