Title : Estradiol pretreatment attenuated nicotine-induced endothelial cell apoptosis via estradiol functional membrane receptor.

Pub. Date : 2011 Jun

PMID : 21262190






2 Functional Relationships(s)
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1 Estradiol-BSA administration was associated with 30% decreased nicotine-induced apoptosis and also attenuated nicotine-activated phosphorylation of p38 and ERK. Nicotine mitogen-activated protein kinase 1 Homo sapiens
2 Clinically, the nicotine in cigarettes might contribute to endothelial dysfunction, whereas ambient estradiol may provide cellular protection against nicotine-induced injury through its functional membrane receptor via MAPK pathway downregulation. Nicotine mitogen-activated protein kinase 1 Homo sapiens