Pub. Date : 2011 Mar
PMID : 21243324
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy. | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 2 | Pancreatic ductal adenocarcinoma (PDAC) still presents a major therapeutic challenge and a phase III clinical trial has revealed that the combination of gemcitabine and a human epidermal growth factor receptor type I (HER1/EGFR) targeting agent presented a significant benefit compared to treatment with gemcitabine alone. | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 3 | Pancreatic ductal adenocarcinoma (PDAC) still presents a major therapeutic challenge and a phase III clinical trial has revealed that the combination of gemcitabine and a human epidermal growth factor receptor type I (HER1/EGFR) targeting agent presented a significant benefit compared to treatment with gemcitabine alone. | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 4 | However, we found that high EGFR expression was an independent prognostic factor in patients receiving gemcitabine-based adjuvant chemotherapy (p=0.023). | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 5 | In conclusion, quantitative analysis of EGFR mRNA expression using FFPE tissue samples and microdissected neoplastic cells from EUS-FNA cytological specimens could be useful in predicting prognosis and sensitivity to gemcitabine in PDAC patients. | gemcitabine | epidermal growth factor receptor | Homo sapiens |