Title : The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

Pub. Date : 2011 Mar 15

PMID : 21241727






1 Functional Relationships(s)
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1 CONCLUSIONS: the impaired defense against mitochondrial superoxide formation in SOD2+/- mice prolongs JNK activation after APAP overdose and consequently further enhances the mitochondrial oxidant stress leading to exaggerated mitochondrial dysfunction, release of intermembrane proteins with nuclear DNA fragmentation and more necrosis. Superoxides mitogen-activated protein kinase 8 Mus musculus