Title : Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism.

Pub. Date : 2011 Apr

PMID : 21224484






2 Functional Relationships(s)
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1 Treatment of constitutive active AMPK restored AAPD-mediated dysregulation of genes involved in both lipid synthesis and fatty acid oxidation. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Moreover, AAPDs decreased transcriptional activity of PPARalpha, a critical transcriptional regulator for controlling hepatic fatty acid oxidation, via an AMPK-dependent manner. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens