Title : Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.

Pub. Date : 2011 Feb

PMID : 21224428






3 Functional Relationships(s)
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1 Bortezomib induces nuclear translocation of IkappaBalpha resulting in gene-specific suppression of NF-kappaB--dependent transcription and induction of apoptosis in CTCL. Bortezomib NFKB inhibitor alpha Homo sapiens
2 We demonstrate that bortezomib and MG132 suppress NF-kappaB activity in Hut-78 cells by a novel mechanism that consists of inducing nuclear translocation and accumulation of IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), which then associates with NF-kappaB p65 and p50 in the nucleus and inhibits NF-kappaB DNA binding activity. Bortezomib NFKB inhibitor alpha Homo sapiens
3 We demonstrate that bortezomib and MG132 suppress NF-kappaB activity in Hut-78 cells by a novel mechanism that consists of inducing nuclear translocation and accumulation of IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), which then associates with NF-kappaB p65 and p50 in the nucleus and inhibits NF-kappaB DNA binding activity. Bortezomib NFKB inhibitor alpha Homo sapiens