Title : Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).

Pub. Date : 2011 Oct

PMID : 21222511






2 Functional Relationships(s)
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1 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical beta-secretase 1 Homo sapiens
2 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical beta-secretase 1 Homo sapiens