Title : Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).

Pub. Date : 2011 Oct

PMID : 21222511






1 Functional Relationships(s)
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1 According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of beta-secretase (BACE1). hydroxychalcones beta-secretase 1 Homo sapiens