Title : Impact of BCR-ABL mutations on patients with chronic myeloid leukemia.

Pub. Date : 2011 Jan 15

PMID : 21220945






2 Functional Relationships(s)
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1 Therapies that target BCR-ABL in chronic myeloid leukemia, including imatinib, dasatinib and nilotinib, have dramatically improved patient outcome. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 In vitro, dasatinib and nilotinib inhibit most imatinib-resistant BCR-ABL mutations, except for T315I. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens