Title : Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth.

Pub. Date : 2011 Jul

PMID : 21215801






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ouabain and cinobufagin significantly inhibited cell proliferation by attenuating the phosphorylation of extracellular regulated kinase (ERK) and down-regulating the expression of C-myc. cinobufagin mitogen-activated protein kinase 1 Homo sapiens
2 Ouabain and cinobufagin significantly inhibited cell proliferation by attenuating the phosphorylation of extracellular regulated kinase (ERK) and down-regulating the expression of C-myc. cinobufagin mitogen-activated protein kinase 1 Homo sapiens
3 Overexpression of ERK reversed the antiproliferation effect of ouabain or cinobufagin in HepG2 and SMMC-7721 cells. cinobufagin mitogen-activated protein kinase 1 Homo sapiens