Title : Distribution of thyrotropin-releasing hormone (TRH) and precursor peptide (TRH-Gly) in adult rat tissues.

Pub. Date : 1990 Nov

PMID : 2121465






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Glycine thyrotropin releasing hormone Rattus norvegicus
2 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Glycine thyrotropin releasing hormone Rattus norvegicus
3 Concentrations of TRH and its precursor peptide (TRH-Gly) were determined in serum and a variety of tissues of the rat using specific RIA systems. Glycine thyrotropin releasing hormone Rattus norvegicus
4 In contrast to the distribution of TRH, relatively higher mean TRH-Gly concentrations were observed in serum (76.5 pg/ml) and in extraneural tissues, including prostate (83.3 pg/mg tissue), spleen (19.0 pg/mg), adrenal (16.2 pg/mg), kidney (13.3 pg/mg), and gastrointestinal tract (6.3-19.8 pg/mg). Glycine thyrotropin releasing hormone Rattus norvegicus
5 Among brain tissues, the TRH-Gly concentration was highest in pituitary gland (13.1 pg/mg). Glycine thyrotropin releasing hormone Rattus norvegicus
6 The mean ratio of TRH-Gly/TRH concentrations was less than 1 in neural tissues and pancreas. Glycine thyrotropin releasing hormone Rattus norvegicus