Pub. Date : 2011 Jan 5
PMID : 21209200
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson"s disease. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Here, we show that the stress-signaling non-receptor tyrosine kinase c-Abl links parkin to sporadic forms of PD via tyrosine phosphorylation. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Our results suggest that tyrosine phosphorylation of parkin by c-Abl is a major post-translational modification that leads to loss of parkin function and disease progression in sporadic PD. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |