Title : An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS.

Pub. Date : 2011 Jan

PMID : 21198441






1 Functional Relationships(s)
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1 The specific CYP substrates used in this cocktail assay included phenacetin (CYP1A2), bupropion (CYP2B6), amodiaquine (CYP2C8), tolbutamide (CYP2C9), S-mephenytoin (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3A4/5). Midazolam cytochrome P450 family 4 subfamily F member 3 Homo sapiens