Title : In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment.

Pub. Date : 2011 Feb 11

PMID : 21194699






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Acetaminophen (CYP1A2), dextrorphan (CYP2D6), hydroxy-chlorzoxazone (CYP2E1) and hydroxy-mephenytoin (CYP2C19) can be derivatized because of the presence of a phenolic OH, whereas hydroxy-midazolam (CYP3A4) and hydroxy-tolbutamide (CYP2C9) remain unchanged. hydroxy-chlorzoxazone cytochrome P450 family 2 subfamily C member 9 Homo sapiens