Title : Rab27a, actin and beta-cell endocytosis.

Pub. Date : 2011

PMID : 21187662






2 Functional Relationships(s)
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1 Since glucose converts Rab27a from the GTP- to GDP-bound form, we suggested that Rab27a plays a crucial role in stimulus-endocytosis coupling in pancreatic beta-cells, and that this is the key molecule for membrane recycling of insulin granules. Guanosine Diphosphate insulin Homo sapiens
2 In this review, we provide an overview of the roles of Rab27a and its GTP- and GDP-dependent effectors in the insulin secretory pathway of pancreatic beta-cells. Guanosine Diphosphate insulin Homo sapiens