Title : Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress.

Pub. Date : 2011 Mar

PMID : 21174067






1 Functional Relationships(s)
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1 Since IkappaBalpha is a substrate of the proteasome, the initial rationale for using BZ in MM has been to inhibit NF-kappaB. Bortezomib NFKB inhibitor alpha Homo sapiens