Pub. Date : 2011 Mar
PMID : 21174062
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A 2"-O-methoxyethylribose-modified phosphorothioate antisense oligonucleotides (ASO) was used to knock-down OPN expression in the human metastatic HCC cell line HCCLM6 and in nude mice orthotopically implanted with HCCLM6 showing highly spontaneous lung metastasis. | Oligonucleotides, Antisense | secreted phosphoprotein 1 | Homo sapiens |
| 2 | Treatment of HCCLM6 cells with OPN ASO inhibited OPN mRNA expression in a dose- and time-dependent manner, whereas the control oligonucleotides had no effect. | Oligonucleotides, Antisense | secreted phosphoprotein 1 | Homo sapiens |
| 3 | Treatment of HCCLM6 cells with OPN ASO inhibited OPN mRNA expression in a dose- and time-dependent manner, whereas the control oligonucleotides had no effect. | Oligonucleotides, Antisense | secreted phosphoprotein 1 | Homo sapiens |
| 4 | OPN ASO significantly suppressed migration and invasion of HCCLM6 cells in vitro. | Oligonucleotides, Antisense | secreted phosphoprotein 1 | Homo sapiens |