Title : Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.

Pub. Date : 1990 Mar-Apr

PMID : 2117268






1 Functional Relationships(s)
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1 The rationale for melanoma specific dihydroxybenzene containing antitumor agents is based in part upon the ability of the enzyme tyrosinase to oxidize these pro drugs to toxic intermediates. hydroquinone tyrosinase Homo sapiens