Title : Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Pub. Date : 2010 Dec 22

PMID : 21172654






1 Functional Relationships(s)
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1 Here, we identify the PIP(3)-Gbetagamma-dependent Rac-GEF P-Rex1 as an essential mediator of Rac1 activation, motility, cell growth, and tumorigenesis driven by ErbB receptors in breast cancer cells. pip(3) phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens