Title : Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.

Pub. Date : 2011 Mar

PMID : 21163968






1 Functional Relationships(s)
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1 Targeted chemical modification of the phenylpiperazine moiety at the site of its interaction with the residue His393(6.55) led to the functionally selective ligand {3-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-yl]-propyl}-pyrazol[1,5-a]pyridine-3-carboxamide (FAUC350) that has distinct signaling profiles toward adenylyl cyclase and ERK1/2. phenylpiperazine mitogen-activated protein kinase 3 Homo sapiens