Pub. Date : 2006 Aug
PMID : 21158076
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity]. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 2 | AIM: To explore IL-6 neuroprotection against glutamate-induced neurotoxicity and primary mechanisms involved in this neuroprotection. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 3 | RESULTS: The chronic IL-6 (2.5, 5 and 10 ng/ml) pretreatment of the cultured cerebellar granule neurons remarkably improved the decreased neuronal vitality by glutamate in a concentration-dependent manner. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 4 | The neuronal apoptosis induced by glutamate was significantly attenuated by the chronic IL-6 pretreatment. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 5 | The intracellular Ca2+ overload evoked by glutamate was also inhibited by the chronic IL-6 pretreatment. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 6 | CONCLUSION: IL-6 can protect neurons against glutamate-induced exciting neurotoxicity. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 7 | The mechanism of IL-6 neuroprotection may be closely related to the suppression of glutamate-induced intracellular Ca2+ overload and mediated by gp130 intracellular signal transduction pathways. | Glutamic Acid | interleukin 6 | Homo sapiens |