Title : Endothelin 1 causes pulmonary vasodilation in rats.

Pub. Date : 1990 Jul

PMID : 2115743






2 Functional Relationships(s)
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1 In blood-perfused lungs undergoing hypoxic (3% O2) vasoconstriction, repeated additions of 0.5 nM ET-1 to the perfusate elicited transient partial vasodilations. Oxygen endothelin 1 Rattus norvegicus
2 In nine conscious rats exposed to 8% O2, intravenous ET-1 (0.2 nmol/kg) reversed the hypoxic pressor response by 63 +/- 8% without affecting cardiac output. Oxygen endothelin 1 Rattus norvegicus