Title : Elicitation of sorbitol accumulation in cultured human proximal tubule cells by elevated glucose concentrations.

Pub. Date : 1990 Aug

PMID : 2115481






1 Functional Relationships(s)
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1 When cells growing 24 h on 27.5 mM glucose were changed to medium containing 5.5 mM glucose, sorbitol concentration returned to the control level within 12 h. The activity of aldose reductase was increased by a factor of 1.6 by exposure to elevated glucose concentrations, and the relative reactivity of the enzyme with glucose as substrate was approximately 0.1 compared with that of glyceraldehyde as substrate. Glyceraldehyde aldo-keto reductase family 1 member B Homo sapiens