Title : ADPRT-mediated decrease of cellular NAD content and the detection of chemically induced DNA damage--development of a new short-term screening test for mutagens.

Pub. Date : 1990

PMID : 2115165






4 Functional Relationships(s)
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1 It was found that the DNA-damaging agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), methyl-methanesulphonate (MMS) and 4-nitroquinoline-N-oxide (4NQO) could stimulate ADP-ribosyl transferase (ADPRT) activity and reduce the cellular NAD content in a dose-dependent way. 4-Nitroquinoline-1-oxide poly(ADP-ribose) polymerase 1 Homo sapiens
2 It was found that the DNA-damaging agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), methyl-methanesulphonate (MMS) and 4-nitroquinoline-N-oxide (4NQO) could stimulate ADP-ribosyl transferase (ADPRT) activity and reduce the cellular NAD content in a dose-dependent way. 4-Nitroquinoline-1-oxide poly(ADP-ribose) polymerase 1 Homo sapiens
3 It was found that the DNA-damaging agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), methyl-methanesulphonate (MMS) and 4-nitroquinoline-N-oxide (4NQO) could stimulate ADP-ribosyl transferase (ADPRT) activity and reduce the cellular NAD content in a dose-dependent way. 4-Nitroquinoline-1-oxide poly(ADP-ribose) polymerase 1 Homo sapiens
4 It was found that the DNA-damaging agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), methyl-methanesulphonate (MMS) and 4-nitroquinoline-N-oxide (4NQO) could stimulate ADP-ribosyl transferase (ADPRT) activity and reduce the cellular NAD content in a dose-dependent way. 4-Nitroquinoline-1-oxide poly(ADP-ribose) polymerase 1 Homo sapiens