Title : The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.

Pub. Date : 2011 Jan

PMID : 21151158






1 Functional Relationships(s)
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1 The guanine nucleotide exchange activity of Vav1 was required for enhancing Bcl-2 promoter activity, and the Vav1 downstream substrate, small GTPase Rac2, was likely involved in the control of Bcl-2 expression. Guanine Nucleotides vav guanine nucleotide exchange factor 1 Homo sapiens