Title : Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone.

Pub. Date : 2011 Mar

PMID : 21148630






3 Functional Relationships(s)
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1 Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone. pegvisomant insulin like growth factor 1 Homo sapiens
2 IGF1 normalized at any time during coadministration in 45 (78.9%) patients (P<0.0001) with median pegvisomant dose at 60 mg/week. pegvisomant insulin like growth factor 1 Homo sapiens
3 CONCLUSIONS: In patients partially controlled by SSAs, LA (120 mg/month) plus pegvisomant normalized IGF1 in 57.9% of patients after 7 months, at a median effective pegvisomant dose of 60 mg/week, and 78.9% at any time. pegvisomant insulin like growth factor 1 Homo sapiens