Title : Enhanced clopidogrel responsiveness in smokers: smokers' paradox is dependent on cytochrome P450 CYP1A2 status.

Pub. Date : 2011 Mar

PMID : 21148426






3 Functional Relationships(s)
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1 Enhanced clopidogrel responsiveness in smokers: smokers" paradox is dependent on cytochrome P450 CYP1A2 status. Clopidogrel cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 CONCLUSIONS: Enhanced clopidogrel response in smokers, known as the smokers" paradox, is not universal but was observed only in cytochrome P450 CYP1A2 (-163C>A) A-allele carriers, suggesting a genotype-dependent effect of smoking on clopidogrel responsiveness. Clopidogrel cytochrome P450 family 1 subfamily A member 2 Homo sapiens
3 CONCLUSIONS: Enhanced clopidogrel response in smokers, known as the smokers" paradox, is not universal but was observed only in cytochrome P450 CYP1A2 (-163C>A) A-allele carriers, suggesting a genotype-dependent effect of smoking on clopidogrel responsiveness. Clopidogrel cytochrome P450 family 1 subfamily A member 2 Homo sapiens